THIS MEDICATION CAN CAUSE HARM TO YOUR BABY:
Use of olanzapine during the third trimester is linked to possible withdrawal symptoms the newborn baby such as agitation, respiratory distress, and feeding issues – it may also increase the risk of gestational diabetes and glucose intolerance in the mother.
What is olanzapine?
Olanzapine is a newer generation antipsychotic medication known as an atypical antipsychotic.
What is olanzapine used to treat?
Olanzapine is prescription medication used to treat bipolar disorder and schizophrenia.
How does olanzapine work?
Olanzapine blocks the effects of dopamine and serotonin in the brain.
If I am taking olanzapine, can it harm my baby?
Olanzapine does cross the human placenta to reach the baby. Studies have reported no serious birth defects associated with olanzapine use during pregnancy; however, prematurity and changes in birth weight (either low or high) have been reported. First trimester exposure to olanzapine is not associated with an increased risk of birth defects. Use of olanzapine during the third trimester is linked to possible withdrawal symptoms in infants such as agitation, respiratory distress, and feeding issues. Olanzapine may also increase the risk of gestational diabetes and glucose intolerance in the mother.
If I am taking olanzapine and become pregnant, what should I do?
It is important that bipolar disorder and schizophrenia therapy be individualized for each patient. The risks should be weighed against the benefits of continuing antipsychotic therapy during pregnancy. Women who are attempting to conceive or become pregnant while on olanzapine should speak with their doctor. Women with chronic or severe disorders may need to continue on olanzapine therapy during pregnancy. Olanzapine is a commonly used antipsychotic in pregnancy.
If I am taking olanzapine, can I safely breastfeed my baby?
Olanzapine is passed to the baby through breast milk. It is estimated that breastfeeding infants receive about 1.8% to 2% of the mother’s dose. Sedation (sleepiness) has been reported in infants exposed to olanzapine though their mother’s breast milk. The dose of olanzapine can be lowered to reduce the risk of side effects in the breastfeeding infant if the mother can tolerate the lower medication dose. Olanzapine is also associated with increased prolactin production which increases breast milk production. It is important to speak with your doctor to determine if continuing on olanzapine is safe during breastfeeding. The American Academy of Pediatrics has stated that antipsychotics have an unknown effect on breastfeeding infants and may be a concern. The manufacturer of olanzapine recommends not breastfeeding while on this medication.
If I am taking olanzapine, will it be more difficult to get pregnant?
Olanzapine may be associated with sexual side effects. Animal studies report impaired sperm production in males. Females may experience decreased fertility or an increase in body fat.
If I am taking olanzapine, what should I know?
Treatment for bipolar disorder or schizophrenia should be individualized during pregnancy. Studies have not shown an increase in birth defects with olanzapine exposure in utero, but further studies need to be conducted. Olanzapine can affect birth weight and can cause withdrawal effects such as respiratory distress in infants. The risk versus benefits of taking or not taking olanzapine should be weighed carefully.
If I am taking any medication, what should I know?
This report provides a summary of available information about the use of atypical antipsychotics during pregnancy and breastfeeding. Content is from the product label unless otherwise indicated.
You may find Pregistry’s expert report about bipolar disorder here, reports about other mental health disorders here, and reports about the individual medications used to treat mental health disorders here. Additional information can also be found in the resources below.
For more information about olanzapine during and after pregnancy, contact http://www.womenshealth.gov/ (800-994-9662 [TDD: 888-220-5446]) or check the following link:
Lilly.com: Zyprexa Prescribing Information