Other Conditions & Exposures

Expert reports about Other Conditions & Exposures


INFORMATION FOR WOMEN WHO HAVE MYASTHENIA GRAVIS DURING PREGNANCY OR BREASTFEEDING

 

What is myasthenia gravis?

Myasthenia gravis (MG) is a disorder of the neuromuscular junction, the connections between nerves and muscles where nerve impulses are transformed into muscle actions. Neuromuscular junctions contain different types of receptors, proteins that respond to a special chemical called acetylcholine that is released from nerve cells to control the corresponding muscle cells. There are different types of acetylcholine receptors. MG results from attack of the immune system on a type of acetylcholine receptor called the nicotinic receptor. The result of the problem with this type of receptor is muscle weakness that gets progressively worse, but that usually is most severe in, and begins first in, small muscles, such as those that control movements of the eye, but ultimately the disease can affect any muscle, including muscles that move the mouth and throat and also the muscles of respiration (breathing).


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